Journal article
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations
Remi Stevelink, Jurjen J Luykx, Bochao D Lin, Costin Leu, Dennis Lal, Alexander W Smith, Dick Schijven, Johannes A Carpay, Koen Rademaker, Roiza A Rodrigues Baldez, Orrin Devinsky, Kees PJ Braun, Floor E Jansen, Dirk JA Smit, Bobby PC Koeleman
EPILEPSIA | WILEY | Published : 2021
DOI: 10.1111/epi.16922
Abstract
OBJECTIVE: Paroxysmal epileptiform abnormalities on electroencephalography (EEG) are the hallmark of epilepsies, but it is uncertain to what extent epilepsy and background EEG oscillations share neurobiological underpinnings. Here, we aimed to assess the genetic correlation between epilepsy and background EEG oscillations. METHODS: Confounding factors, including the heterogeneous etiology of epilepsies and medication effects, hamper studies on background brain activity in people with epilepsy. To overcome this limitation, we compared genetic data from a genome-wide association study (GWAS) on epilepsy (n = 12 803 people with epilepsy and 24 218 controls) with that from a GWAS on background E..
View full abstractGrants
Awarded by Science Foundation Ireland
Awarded by Wellcome Trust
Awarded by Epilepsy Society, UK, NIHR
Awarded by GIHE
Awarded by GSCFE
Awarded by NIH
Awarded by NHMRC
Awarded by European Union's Seventh Framework Programme (FP7/2007-2013)
Awarded by Department of Health's NIHR Biomedical Research Centers funding scheme, European Community
Awarded by German Research Foundation
Awarded by European Science Foundation
Awarded by German Federal Ministry of Education and Research, National Genome Research Network
Awarded by Netherlands National Epilepsy Fund
Awarded by Research Grants Council of the Hong Kong Special Administrative Region
Awarded by NIHR Biomedical Research Centres Schem
Awarded by Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awarded by German Ministry for Education and Research
Awarded by Science Foundation Ireland (SFI)
Funding Acknowledgements
Science Foundation Ireland, Grant/Award Number: 16/RC/3948 and 13/CDA/2223; European Regional Development Fund; FutureNeuro industry partners; Wellcome Trust, Grant/Award Number: 084730 and WT066056; Epilepsy Society, UK, NIHR, Grant/Award Number: 08--08-SCC; GIHE, Grant/Award Number: NIH R01--NS--49306--01 and NIH R01--NS--053998; GSCFE, Grant/Award Number: NIH R01--NS--064154--01; NIH, Grant/Award Number: UL1TR001070; The Children's Hospital of Philadelphia; NHMRC, Grant/Award Number: 1091593; The Royal Melbourne Hospital Foundation Lottery Grant; The RMH Neuroscience Foundation; European Union's Seventh Framework Programme (FP7/2007--2013), Grant/Award Number: 279062; Department of Health's NIHR Biomedical Research Centers funding scheme, European Community, Grant/Award Number: LSHM--CT2006--037315; German Research Foundation, Grant/Award Number: SA434/4--1/4--26--1; European Science Foundation, Grant/Award Number: SA434/5--1, NU50/8--1, LE1030/11--1, HE5415/3--1 and RO 3396/2--1; German Federal Ministry of Education and Research, National Genome Research Network, Grant/Award Number: 01GS08120 and 01GS08123; The Netherlands National Epilepsy Fund, Grant/Award Number: 04--08; Research Grants Council of the Hong Kong Special Administrative Region, Grant/Award Number: HKU7623/08 M, HKU7747/07 M and CUHK4466/06 M; Fonds National de la Recherche Scientifique; Fondation Erasme; Universite Libre de Bruxelles; NIHR Biomedical Research Centres Schem, Grant/Award Number: P31753; Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Number: N01HD33348; German Ministry for Education and Research, Grant/Award Number: 01EY1103; Helmholtz Zentrum Munchen - German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria; Helmholtz Zentrum Munchen--German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria; Munich Center of Health Sciences; Ludwig Maximilian University, as part of LMUinnovativ